The carcinostatic activity of 5-hydroxy-2-formylpyridine thiosemicarbazone.

نویسندگان

  • E J Blanz
  • F A French
چکیده

5 -Hydroxy-2-formylpyridine thiosemicarbazone (5-HP) is highly active intraperitoneally against leukemia L-1210, Ehrlich ascites carcinoma, and lymphoma L-5 178Y over a broad dose range. 5-HP is also active on leukemia L-l210 and the Ehrlich ascites carcinoma by delayed treatment. Activity by oral routes or subcutaneously is poor. Moderate activity is displayed against the Lewis lung carcinoma and adenocarcin oma 755 . 5-lIP is the most active antileukemic agent in this series to date.

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منابع مشابه

The Carcinostatic Activity of 5-Hydroxy-2-formylpyridine

5 -Hydroxy-2-formylpyridine thiosemicarbazone (5-HP) is highly active intraperitoneally against leukemia L-1210, Ehrlich ascites carcinoma, and lymphoma L-5 178Y over a broad dose range. 5-HP is also active on leukemia L-l210 and the Ehrlich ascites carcinoma by delayed treatment. Activity by oral routes or subcutaneously is poor. Moderate activity is displayed against the Lewis lung carcinoma ...

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The carcinostatic activity of alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones. II. 3-Hydroxypyridine-2-carboxaldehyde thiosemicarbazone.

3-Hydroxypy rid ine-2-carboxaldehyf le thiosemicarbazone (3-HP) has been shown to be active against leukemia L1210, Ehrlich ascites carcinoma, lym]>homa L5178Y, the Lewis lung carcinoma, and adenocarcinoma 755. 3-HP is active, in some in stances, by gavage and also by delayed treatment. 3-HP is a member of a broad class of a-(.Y)-heterocyclic carboxaldehyde thiosemicarbazones, several of which ...

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عنوان ژورنال:
  • Cancer research

دوره 28 12  شماره 

صفحات  -

تاریخ انتشار 1968